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Common Name: Oldenlandia diffusaw (Bai Hua She She Cao)
Clinical Summary: Oldenlandia diffusa, an herb prevalent in East Asia and Southern China, is used in traditional Chinese medicine to clear "heat" and to eliminate "toxins". It is used in combination with other herbs for the treatment of hepatitis, snake bite (1), tumors of the liver, lung, stomach (1), and rectum (2). Studies conducted in vitro and in animals suggest that Oldenlandia diffusa possesses anticancer and chemopreventive properties (2)(3)(4)(5)(6). Oleanolic and Ursolic acids, compounds isolated from Oldenlandia diffusa, demonstrated cytotoxic activity (7)(8). Ursolic acid also showed anti-inflammatory effects in mice with rheumatoid arthritis (9); a few other compounds inhibited low-density lipoprotein (LDL) oxidation in mice.
More research is necessary to determine whether Oldenlandia diffusa can be used as a safe and effective anticancer agent in humans.
References:
1. Liang Z, He M, Fong W, Jiang Z, Zhao Z. A comparable, chemical and pharmacological analysis of the traditional Chinese medicinal herbs Oldenlandia diffusa and O. corymbosa and a new valuation of their biological potential.Phytomedicine. Apr 2008;15(4):259-267.
2. Wong BY, Lau BH, Jia TY, Wan CP. Oldenlandia diffusa and Scutellaria barbata augment macrophage oxidative burst and inhibit tumor growth. Cancer Biother Radiopharm. Feb 1996;11(1):51-56.
3. Gupta S, Zhang D, Yi J, Shao J. Anticancer activities of Oldenlandia diffusa. J Herb Pharmacother. 2004;4(1):21-33.
4. Yadav SK, Lee SC. Evidence for Oldenlandia diffusa-evoked cancer cell apoptosis through superoxide burst and caspase activation. Zhong Xi Yi Jie He Xue Bao. Sep 2006;4(5):485-489.
5. Shan BE, Zhang JY, Du XN. [Immunomodulatory activity and anti-tumor activity of Oldenlandia diffusa in vitro]. Zhongguo Zhong Xi Yi Jie He Za Zhi. May 2001;21(5):370-374.
6. Willimott S, Barker J, Jones LA, Opara EI.Apoptotic effect of Oldenlandia diffusa on the leukaemic cell line HL60 and human lymphocytes. J Ethnopharmacol. Dec 3 2007;114(3):290-299.
7. Wu PK, Chi Shing Tai W, Liang ZT, Zhao ZZ, Hsiao WL. Oleanolic acid isolated from Oldenlandia diffusa exhibits a unique growth inhibitory effect against ras-transformed fibroblasts. Life Sci. Jul 17 2009;85(3-4):113-121.
8. Yang L, Liu X, Lu Z, et al. Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. Cancer Lett. 2010;298(1):128-138. Epub 2010 Jul 13.
9. Kang SY, Yoon SY, Roh DH, et al. The anti-arthritic effect of ursolic acid on zymosan-induced acute inflammation and adjuvant-induced chronic arthritis models. J Pharm Pharmacol. Oct 2008;60(10):1347-1354.
10. Liang ZT, Jiang ZH, Leung KS, Peng Y, Zhao ZZ. Distinguishing the medicinal herb Oldenlandia diffusa from similar species of the same genus using fluorescence microscopy.Microsc Res Tech. Apr 2006;69(4):277-282.
11. Chen JK, Chen TT. Chinese Medical Herbology and Pharmacology, 2nd ed. California:Art of Medicine Press;2004.
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